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Joined 2 years ago
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Cake day: August 13th, 2024

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  • Apparently 5 of 9 musical acts have cancelled, stating generally that they were misled regarding the nature of the event. Enormous thanks to the artists who have cancelled, from your old fans and new fans worldwide!!

    "After the lineup for the concerts was announced, the hip-hop artist Young MC said he would not perform, adding that “artists were never told about any political involvement with the event.” The funk-soul group the Commodores, the rock musician Bret Michaels and Morris Day and the Time also canceled performances.

    “Unfortunately, what was presented to us as a celebration of our country has evolved into something much more divisive than what I agreed to be part of,” Mr. Michaels, the frontman of the rock group Poison, wrote on social media."





  • Preservative food additives, hypertension, and cardiovascular diseases: the NutriNet-Santé study https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag308/8679203?login=false

    Abstract Background and Aims Experimental studies suggest that some preservative food additives may exert adverse cardiovascular effects, yet human data are lacking. The associations between exposure to these compounds and incidence of hypertension and cardiovascular diseases (CVD) were investigated in the NutriNet-Santé cohort (France, 2009–2024). … Methods Dietary intakes were assessed using repeated 24-h dietary records (up to 96), including commercial brands. Exposure to food additives was evaluated through multiple composition databases and ad hoc laboratory assays in food matrices. Associations between cumulative time-dependent exposures to preservative food additives during follow-up and outcomes were characterized using multi-adjusted Cox models. … Results Overall, 112 395 participants were included (78.7% women, mean age 42.8 ± 14.7 years) with a median follow- up of 7.9 years. The sum of total preservatives encompassed 58 substances consumed by at least one participant. Total non-antioxidant preservatives were positively associated with higher incidences of hypertension [n = 5544; hazard ratio (HR) higher vs. lower consumers: 1.29, 95% confidence interval (CI) 1.20–1.39] and CVD (n = 2450; HR 1.16, 95% CI 1.04–1.29), while total antioxidant preservatives were associated with higher incidence of hypertension (HR 1.22, 95% CI 1.13–1.31). Out of the 17 individual preservative food additives consumed by at least 10% of the study population, eight were associated with higher incidence of hypertension and one with higher incidence of CVD, after multiple test correction. … Conclusions Multiple associations between exposure to preservative food additives widely used in industrial foods and higher incidence of hypertension or CVD were observed in this large prospective cohort. Experimental research is needed to gain insight into underlying mechanisms. If confirmed, these new data call for the re-evaluation of regulations governing the use of these additives to improve consumer protection. … Trial Registration ClinicalTrials.gov NCT03335644.












  • Get the shot, don’t be a fool like Fischer. It’s not only about protecting you; it’s also about protecting the people around you from adverse consequences. Viral infection don’t just cause short term effects, there are a host of long-term issues that can show up with nearly every (only being cautious with my wording here) infection. SARS-CoV-2 - even a mild infection carries with it 3 months of increased cardiovascular risk, a year of decreased cognitive function. Similarly with influenza, RSV, CMV, etc, etc. Get the shot, wash your hands, wear a mask, and encourage those you know and care about to do the same. Some of what we have thought of as “normal aging” is in fact long-term effects from infectious disease. You are gonna age, you are gonna die, but why would anyone want to speed up the process of degradation?

    Beyond the acute phase: a comprehensive literature review of long-term sequelae resulting from infectious diseases https://pmc.ncbi.nlm.nih.gov/articles/PMC10864624/